ESTABLISHMENT OF THE JAPANESE STANDARD FOR HUMAN COAGULATION FACTOR IX
نویسندگان
چکیده
منابع مشابه
Coagulation Factor IX for Hemophilia B Therapy
Factor IX is a zymogen enzyme of the blood coagulation cascade. Inherited absence or deficit of the IX functional factor causes bleeding disorder hemophilia B, which requires constant protein replacement therapy. Reviewed herein are the current state in the manufacturing of FIX, improved variants of the recombinant protein for therapy, transgenic organisms for obtaining FIX, and the advances in...
متن کاملProteolytic processing of human coagulation factor IX by plasmin.
Previous studies have shown that thrombin generation in vivo caused a 92% decrease in factor IX (F.IX) activity and the appearance of a cleavage product after immunoblotting that comigrated with activated F.IX (F.IXa). Under these conditions, the fibrinolytic system was clearly activated, suggesting plasmin may have altered F.IX. Thus, the effect(s) of plasmin on human F.IX was determined in vi...
متن کاملCSL Behring Coagulation Factor IX ( Human ) Mononine ® Monoclonal Antibody Purified
only DESCRIPTION Coagulation Factor IX (Human), Mononine, is a sterile, stable, lyophilized concentrate of Factor IX prepared from pooled human plasma and is intended for use in therapy of Factor IX deficiency, known as Hemophilia B or Christmas disease. Mononine is purified of extraneous plasma-derived proteins, including Factors II, VII and X, by use of immunoaffinity chromatography. A murine...
متن کاملThe effect of platelets in the activation of human blood coagulation factor IX by factor XIa.
We report here the effect of activated human platelets on the activation of human factor IX by human factor XIa. Factor IXa formed during activation was determined via its ability to activate bovine factor X. To increase sensitivity, phospholipids and bovine factor VIIIa were present in the assay. The kinetic parameters of the factor IX activation were determined in the presence of 10 mmol/L Ca...
متن کاملStructural and functional basis of the developmental regulation of human coagulation factor IX gene: factor IX Leyden.
Hemophilia B Leyden is characterized by unusual developmental regulation of factor IX synthesis in affected individuals. One family affected with the hemophilia B Leyden phenotype was found to have a specific single-base mutation (G----A) at nucleotide -6 of the factor IX gene. The mutation site was found in a small region of the 5'-untranslated sequence designated the Leyden-specific region (L...
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ژورنال
عنوان ژورنال: Japanese Journal of Transfusion and Cell Therapy
سال: 2008
ISSN: 1881-3011,1883-0625
DOI: 10.3925/jjtc.54.43